3D Environment Is Required In Vitro to Demonstrate Altered Bone Metabolism Characteristic for Type 2 Diabetics.

Häussling, Victor; Aspera-Werz, Romina H; Rinderknecht, Helen; Springer, Fabian; Arnscheidt, Christian; Menger, Maximilian M; Histing, Tina; Nussler, Andreas K; Ehnert, Sabrina

Häussling, Victor; Aspera-Werz, Romina H; Rinderknecht, Helen; Springer, Fabian; Arnscheidt, Christian; Menger, Maximilian M; Histing, Tina; Nussler, Andreas K; Ehnert, Sabrina.

Afiliação

Häussling V; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Aspera-Werz RH; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Rinderknecht H; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Springer F; Department of Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany.
Arnscheidt C; Radiology Department, BG Trauma Center Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Menger MM; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Histing T; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Nussler AK; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.
Ehnert S; Siegfried Weller Research Institute, BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, D-72076 Tübingen, Germany.

Int J Mol Sci ; 22(6)2021 Mar 13.

Article em En | MEDLINE | ID: mdl-33805833

Assuntos

Osso e Ossos/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Redes e Vias Metabólicas/genética; Osteoblastos/metabolismo; Osteoclastos/metabolismo; Fosfatase Alcalina/genética; Fosfatase Alcalina/metabolismo; Reabsorção Óssea/genética; Reabsorção Óssea/metabolismo; Reabsorção Óssea/patologia; Osso e Ossos/patologia; Calcificação Fisiológica/genética; Anidrase Carbônica II/genética; Anidrase Carbônica II/metabolismo; Catepsina K/genética; Catepsina K/metabolismo; Diferenciação Celular; Linhagem Celular Tumoral; Técnicas de Cocultura; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/patologia; Regulação da Expressão Gênica; Humanos; Modelos Biológicos; Osteoblastos/patologia; Osteoclastos/patologia; Osteoprotegerina/genética; Osteoprotegerina/metabolismo; Ligante RANK/genética; Ligante RANK/metabolismo; Células THP-1; Fosfatase Ácida Resistente a Tartarato/genética; Fosfatase Ácida Resistente a Tartarato/metabolismo; Alicerces Teciduais

Palavras-chave

3D coculture; bone metabolism; cryogel; diabetes mellitus; osteoblast; osteoclast; scaffold

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoblastos / Osteoclastos / Osso e Ossos / Diabetes Mellitus Tipo 2 / Redes e Vias Metabólicas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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