Production of Pyracantha Polysaccharide-Iron(III) Complex and Its Biologic Activity.
Molecules
; 26(7)2021 Mar 30.
Article
em En
| MEDLINE
| ID: mdl-33808420
ABSTRACT
In this study, the optimum synthetic process of the Pyracantha polysaccharide-iron (PPI) complex was studied via response surface methodology (RSM). Its antioxidant and anti-cancer activities were also investigated. It was demonstrated that the optimal conditions for the synthetic process of the complex were as follows a pH of 8.9, a reaction temperature of 70 °C and a trisodium citratepolysaccharide ratio of 12. PPI were analysis by UV, FTIR, SEM, CD, XRD, TGA and NMR. PPI was able to scavenge the metal ion, ABTS and free radicals of the superoxide anion, demonstrating its potential antioxidant activity. PPI was found to display cytotoxicity to Skov3 cells, as shown by its ability to induce apoptosis and alter gene expression in Skov3 cells. These findings show than PPI may represent a novel antioxidant and chemotherapeutic drug.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Produtos Biológicos
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Compostos Férricos
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Sequestradores de Radicais Livres
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Pyracantha
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article