Safety and Efficacy of Ustekinumab in the Inflammatory Bowel Disease of Chronic Granulomatous Disease.

Bhattacharya, Sumona; Marciano, Beatriz E; Malech, Harry L; Quezado, Martha; Holland, Steven M; De Ravin, Suk See; Zerbe, Christa S; Heller, Theo

Bhattacharya, Sumona; Marciano, Beatriz E; Malech, Harry L; Quezado, Martha; Holland, Steven M; De Ravin, Suk See; Zerbe, Christa S; Heller, Theo.

Afiliação

Bhattacharya S; Digestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: Sumona.bhattacharya@nih.gov.
Marciano BE; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Malech HL; Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Quezado M; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Holland SM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
De Ravin SS; Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Zerbe CS; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Heller T; Translational Hepatology Section, Liver Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: theoh@intra.niddk.nih.gov.

Clin Gastroenterol Hepatol ; 20(2): 461-464.e2, 2022 02.

Article em En | MEDLINE | ID: mdl-33813069

ABSTRACT

ABSTRACT

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by mutations encoding the NADPH oxidase complex.1 Those affected are at increased risk of bacterial and fungal infections and require antimicrobial prophylaxis. Dysregulated inflammation may cause inflammatory bowel disease (IBD), termed CGD-associated IBD or CGD colitis, a distinct entity from Crohn's disease (CD) or ulcerative colitis (UC).

Assuntos

Colite Ulcerativa; Colite; Doença de Crohn; Doença Granulomatosa Crônica; Doenças Inflamatórias Intestinais; Colite/complicações; Colite Ulcerativa/complicações; Doença de Crohn/complicações; Doença Granulomatosa Crônica/complicações; Doença Granulomatosa Crônica/tratamento farmacológico; Doença Granulomatosa Crônica/genética; Humanos; Doenças Inflamatórias Intestinais/complicações; Doenças Inflamatórias Intestinais/tratamento farmacológico; Ustekinumab/efeitos adversos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn / Colite / Doença Granulomatosa Crônica Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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