Establishment and characterization of 38 novel patient-derived primary cancer cell lines using multi-region sampling revealing intra-tumor heterogeneity of gallbladder carcinoma.

Feng, Feiling; Cheng, Qingbao; Li, Bin; Liu, Chen; Wang, Huizhen; Li, Bin; Xu, Xiaoya; Yu, Yong; Chen, Zishuo; Wu, Xiaobing; Dong, Hua; Chu, Kaijian; Xie, Zhenghua; Gao, Qingxiang; Xiong, Lei; Li, Fugen; Yi, Bin; Zhang, Dadong; Jiang, Xiaoqing

Feng, Feiling; Cheng, Qingbao; Li, Bin; Liu, Chen; Wang, Huizhen; Li, Bin; Xu, Xiaoya; Yu, Yong; Chen, Zishuo; Wu, Xiaobing; Dong, Hua; Chu, Kaijian; Xie, Zhenghua; Gao, Qingxiang; Xiong, Lei; Li, Fugen; Yi, Bin; Zhang, Dadong; Jiang, Xiaoqing.

Afiliação

Feng F; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Cheng Q; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Li B; 3D Medicines Inc., Shanghai, 201114, China.
Liu C; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Wang H; 3D Medicines Inc., Shanghai, 201114, China.
Li B; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Xu X; 3D Medicines Inc., Shanghai, 201114, China.
Yu Y; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Chen Z; 3D Medicines Inc., Shanghai, 201114, China.
Wu X; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Dong H; 3D Medicines Inc., Shanghai, 201114, China.
Chu K; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Xie Z; 3D Medicines Inc., Shanghai, 201114, China.
Gao Q; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Xiong L; 3D Medicines Inc., Shanghai, 201114, China.
Li F; 3D Medicines Inc., Shanghai, 201114, China.
Yi B; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China.
Zhang D; 3D Medicines Inc., Shanghai, 201114, China. dadong.zhang@3dmedcare.com.
Jiang X; Department of Biliary I, Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai, 200438, China. xqjiang_dandaoyike@163.com.

Hum Cell ; 34(3): 918-931, 2021 May.

Article em En | MEDLINE | ID: mdl-33813726

Assuntos

Carcinoma/genética; Carcinoma/patologia; Neoplasias da Vesícula Biliar/genética; Neoplasias da Vesícula Biliar/patologia; Heterogeneidade Genética; Carcinogênese/genética; Linhagem Celular Tumoral; Inibidor p16 de Quinase Dependente de Ciclina/genética; Proteínas de Ligação a DNA/genética; Progressão da Doença; Regulação Neoplásica da Expressão Gênica/genética; Genes MHC Classe I; Genes MHC da Classe II; Humanos; Mutação; Proteínas Nucleares/fisiologia; Transativadores/fisiologia; Fatores de Transcrição/genética; Proteína Supressora de Tumor p53/genética

Palavras-chave

Gallbladder carcinoma; Genomic profiling; Intra-tumor heterogeneity; Patient-derived primary cancer cell line; Transcriptome profiling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma / Heterogeneidade Genética / Neoplasias da Vesícula Biliar Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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