Vitamin D Level Stability in Dystrophinopathy Patients on Vitamin D Supplementation.
J Neuromuscul Dis
; 8(4): 481-487, 2021.
Article
em En
| MEDLINE
| ID: mdl-33814459
ABSTRACT
BACKGROUND:
Expert guidelines recommend annual monitoring of 25-hydroxyvitamin D (25-OHD) and maintaining 25-OHD ≥30âng/ml in patients with dystrophinopathies.OBJECTIVE:
We hypothesized that 25-OHD remains stable and requires less frequent monitoring in patients taking stable maintenance doses of vitamin D.METHODS:
We performed a retrospective cohort study, using the electronic health record to identify 26 patients with dystrophinopathies with a baseline 25-OHD ≥30âng/mL and at least one additional 25-OHD measurement. These patients had received a stable dose of vitamin D for ≥3 months prior to their baseline 25-OHD measurement and throughout follow-up. The main outcome measured was the mean duration time the subjects spent with a 25-OHD ≥30 ng/mL.RESULTS:
Only 19% of patients dropped their 25-OHD to <â30âng/ml, with a mean time to drop of 33 months and a median nadir 25-OHD of 28âng/mL.CONCLUSIONS:
These results suggest that measurement of 25-OHD every 2-2.5 years may be sufficient in patients with a baseline 25-OHD ≥30âng/mL and who are on a stable maintenance dose of vitamin D. Other patients may require more frequent assessments.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
/
Suplementos Nutricionais
/
Distrofias Musculares
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
/
Child
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article