[Bacteriophage Therapy: Retrospective Review and Future Prospects].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 52(2): 170-175, 2021 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-33829687
ABSTRACT
At present, bacterial infections are mainly treated with antibiotics, but new treatment methods are urgently needed because of growing problems with antibiotic resistance. Therefore, phage therapy will be a potential solution to the problem of bacterial drug resistance, and the combined use of bacteriophage and antibiotics is also considered a potential treatment option. However, there has not been any well-designed clinical controlled trials on phage therapy. More future research needs to be done to solve the problems of phage therapy, for example, its narrow antibacterial spectrum, the uncertainty regarding treatment safety, and the bacterial resistance. Some refractory diseases such as breast cancer and alcoholic hepatitis are difficult to treat clinically. The successful experimental research on bacteriophages reported in these fields provides new ideas of treatment for more refractory diseases in the future. In addition, bacteriophages also showed promising performance in vaccine applications and osteanagenesis. We herein summarize the existing weaknesses of phage therapy and its application prospects in treating systemic diseases, hoping to promote further clinical application research of phage therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Bacteriófagos
/
Terapia por Fagos
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2021
Tipo de documento:
Article