Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory.
Proc Natl Acad Sci U S A
; 118(15)2021 04 13.
Article
em En
| MEDLINE
| ID: mdl-33833054
ABSTRACT
Learning and memory are assumed to be supported by mechanisms that involve cholinergic transmission and hippocampal theta. Using G protein-coupled receptor-activation-based acetylcholine sensor (GRABACh3.0) with a fiber-photometric fluorescence readout in mice, we found that cholinergic signaling in the hippocampus increased in parallel with theta/gamma power during walking and REM sleep, while ACh3.0 signal reached a minimum during hippocampal sharp-wave ripples (SPW-R). Unexpectedly, memory performance was impaired in a hippocampus-dependent spontaneous alternation task by selective optogenetic stimulation of medial septal cholinergic neurons when the stimulation was applied in the delay area but not in the central (choice) arm of the maze. Parallel with the decreased performance, optogenetic stimulation decreased the incidence of SPW-Rs. These findings suggest that septo-hippocampal interactions play a task-phase-dependent dual role in the maintenance of memory performance, including not only theta mechanisms but also SPW-Rs.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ritmo Teta
/
Neurônios Colinérgicos
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Hipocampo
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Memória de Curto Prazo
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article