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Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis.
Wang, Heng; Xu, Min; Engelhart, Curtis A; Zhang, Xi; Yan, Baohua; Pan, Miaomiao; Xu, Yuanyuan; Fan, Shilong; Liu, Renhe; Xu, Lan; Hua, Lan; Schnappinger, Dirk; Chen, Shawn.
Afiliação
  • Wang H; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Xu M; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Engelhart CA; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
  • Zhang X; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Yan B; Center of Protein Science Facility, Tsinghua University, Beijing, China.
  • Pan M; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Xu Y; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Fan S; Center of Protein Science Facility, Tsinghua University, Beijing, China.
  • Liu R; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Xu L; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Hua L; Global Health Drug Discovery Institute, Haidian, Beijing, China.
  • Schnappinger D; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
  • Chen S; Global Health Drug Discovery Institute, Haidian, Beijing, China. Electronic address: schen169@hotmail.com.
J Biol Chem ; 296: 100257, 2021.
Article em En | MEDLINE | ID: mdl-33837735
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilalanina-tRNA Ligase / Conformação Proteica / Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilalanina-tRNA Ligase / Conformação Proteica / Tuberculose Resistente a Múltiplos Medicamentos / Mycobacterium tuberculosis Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article