Pilot assessment of omega-3 fatty acids and potassium thiocyanate in sickle cell anemia patients with conditional peak systolic cerebral artery blood velocity.
Blood Cells Mol Dis
; 89: 102564, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33839465
ABSTRACT
OBJECTIVE:
The purpose of this pilot study was to explore the effect of omega-3 fatty acids and potassium thiocyanate on conditional peak systolic cerebral artery blood velocity in children with sickle cell anemia (SCA).METHODS:
Transcranial doppler ultrasonography (TCD) was done on 232 SCA children, and 21 found with conditional peak systolic blood velocity (PSV) of 200-249â¯cm/s in internal carotid, middle or anterior cerebral arteries. These were randomized to receive omega-3 fatty acids and potassium thiocyanate with standard treatment of SCA (test group, Nâ¯=â¯14), or standard treatment only (control group, Nâ¯=â¯7). After 3â¯months of treatment, PSV was measured again.RESULTS:
Right middle cerebral artery PSV was significantly reduced in the test relative to the control groups (pâ¯=â¯0.04). PSV returned to normal in 79% of the test versus 43% of the control group; and increased to abnormal in one member of the control group, but none of the test group.CONCLUSIONS:
The pilot data suggest that in SCA, omega-3 fatty acids and potassium thiocyanate might reduce conditional blood velocity to normal, or prevent progression to abnormal values. A larger, randomized, clinical trial is required to further address the current gap in management of conditional TCD blood velocity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiocianatos
/
Ácidos Graxos Ômega-3
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Artérias Cerebrais
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Anemia Falciforme
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article