Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives as potential &#945;-glucosidase inhibitors.

Shareghi-Boroujeni, Diba; Iraji, Aida; Mojtabavi, Somayeh; Faramarzi, Mohammad Ali; Akbarzadeh, Tahmineh; Saeedi, Mina

Synthesis, in vitro evaluation, and molecular docking studies of novel hydrazineylideneindolinone linked to phenoxymethyl-1,2,3-triazole derivatives as potential α-glucosidase inhibitors.

Shareghi-Boroujeni, Diba; Iraji, Aida; Mojtabavi, Somayeh; Faramarzi, Mohammad Ali; Akbarzadeh, Tahmineh; Saeedi, Mina.

Afiliação

Shareghi-Boroujeni D; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Iraji A; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mojtabavi S; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran 1417614411, Iran.
Faramarzi MA; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran 1417614411, Iran.
Akbarzadeh T; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Saeedi M; Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: m-saeedi@tums.ac.ir.

Bioorg Chem ; 111: 104869, 2021 06.

Article em En | MEDLINE | ID: mdl-33839583

Assuntos

Inibidores de Glicosídeo Hidrolases/farmacologia; Simulação de Acoplamento Molecular; Oxindóis/farmacologia; Triazóis/farmacologia; alfa-Glucosidases/metabolismo; Relação Dose-Resposta a Droga; Inibidores de Glicosídeo Hidrolases/síntese química; Inibidores de Glicosídeo Hidrolases/química; Humanos; Estrutura Molecular; Oxindóis/química; Relação Estrutura-Atividade; Triazóis/química

Palavras-chave

1,2,3-Triazole; Click reaction; Diabetes; Docking study; Hydrazineylideneindolinone; α-Glucosidase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Alfa-Glucosidases / Simulação de Acoplamento Molecular / Inibidores de Glicosídeo Hidrolases / Oxindóis Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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