Simultaneous Detection of Six Isoforms of Tau Protein in Human Cerebrospinal Fluid by Multidimensional Mass Spectrometry-Based Targeted Proteomics.

Xu, Mengying; Lu, Meiyan; Zhang, Wenjun; Jin, Qingwen; Chen, Yun

Xu, Mengying; Lu, Meiyan; Zhang, Wenjun; Jin, Qingwen; Chen, Yun.

Afiliação

Xu M; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Lu M; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Zhang W; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Jin Q; Sir Run Run Hospital Affiliated to Nanjing Medical University, Nanjing 211100, China.
Chen Y; School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.

J Proteome Res ; 20(5): 2299-2307, 2021 05 07.

Article em En | MEDLINE | ID: mdl-33843226

Assuntos

Doença de Alzheimer; Proteínas tau; Doença de Alzheimer/diagnóstico; Biomarcadores; Cromatografia Líquida; Humanos; Espectrometria de Massas; Isoformas de Proteínas; Proteômica; Reprodutibilidade dos Testes

Palavras-chave

Alzheimer's disease; SDS-PAGE; Tau protein isoforms; mass spectrometry-based targeted proteomics; multidimensional separation; system of linear equations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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