Plasmodium infection prevents recurrence and metastasis of hepatocellular carcinoma possibly via inhibition of the epithelialmesenchymal transition.
Mol Med Rep
; 23(6)2021 06.
Article
em En
| MEDLINE
| ID: mdl-33846776
ABSTRACT
Postoperative recurrence causes a high mortality rate among patients with hepatocellular carcinoma (HCC). The current study aimed to determine the effects of Plasmodium infection on HCC metastasis and recurrence. The antitumor effects of Plasmodium infection were determined using two murine orthotopic HCC models The nonresection model and the resection model. Tumour tissues derived from tumourbearing mice treated with or without Plasmodium infection were harvested 15 days posttumour inoculation. The expression levels of biomarkers related to epithelialmesenchymal transition (EMT) and molecules associated with CCchemokine receptor 10 (CCR10)mediated PI3K/Akt/GSK3ß/Snail signalling were identified using reverse transcriptionquantitative PCR and western blotting. The results demonstrated that Plasmodium infection significantly suppressed the progression, recurrence and metastasis of HCC in the two mouse models. The expression levels of Ecadherin were significantly higher in the Plasmodiumtreated group compared with that in the control group, whereas the expression levels of Vimentin and Snail were significantly lower in the Plasmodiumtreated group. Furthermore, Plasmodium infection inhibited the activation of Akt and GSK3ß in the tumour tissues by downregulating the expression levels of CCR10 and subsequently suppressing the accumulation of Snail, which may contribute to the suppression of EMT and the prevention of tumour recurrence and metastasis. In conclusion, the results of the present study demonstrated that Plasmodium infection inhibited the recurrence and metastasis and improved the prognosis of HCC by suppressing CCR10mediated PI3K/Akt/GSK3ß/Snail signalling and preventing the EMT. These results may be important for the development of novel therapies for HCC recurrence and metastasis, especially for patients in the perioperative period.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
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Transição Epitelial-Mesenquimal
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Neoplasias Hepáticas
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Malária
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article