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Taxonomy of the Trichophyton mentagrophytes/T. interdigitale Species Complex Harboring the Highly Virulent, Multiresistant Genotype T. indotineae.
Tang, Chao; Kong, Xue; Ahmed, Sarah A; Thakur, Rameshwari; Chowdhary, Anuradha; Nenoff, Pietro; Uhrlass, Silke; Verma, Shyam B; Meis, Jacques F; Kandemir, Hazal; Kang, Yingqian; de Hoog, G Sybren.
Afiliação
  • Tang C; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Key Laboratory of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, China.
  • Kong X; Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
  • Ahmed SA; Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Nanjing, 0210042, China.
  • Thakur R; Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
  • Chowdhary A; Department of Dermatology and Microbiology, Muzaffarnagar Medical College and Hospital, Chaudhary Charan Singh University, Meerut, India.
  • Nenoff P; Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
  • Uhrlass S; Laboratory for Medical Microbiology, Mölbis, Germany.
  • Verma SB; Laboratory for Medical Microbiology, Mölbis, Germany.
  • Meis JF; Nirvan" and "In Skin" Clinics, Vadodara, India.
  • Kandemir H; Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
  • Kang Y; Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
  • de Hoog GS; Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
Mycopathologia ; 186(3): 315-326, 2021 Jun.
Article em En | MEDLINE | ID: mdl-33847867
ABSTRACT
A severe outbreak of highly virulent and multi-resistant dermatophytosis by species in the Trichophyton mentagrophytes/T. interdigitale complex is ongoing in India. The correct identity of the etiologic agent is a much-debated issue. In order to define species limits, a taxonomic study was undertaken combining molecular, morphological, and physiological characteristics as evidence of classification. Molecular characteristics show that T. mentagrophytes s. str. and T. interdigitale s. str. can be distinguished with difficulty from each other, but are unambiguously different from the Indian genotype, T. indotineae by sequences of the HMG gene. The entities were confirmed by multilocus analysis using tanglegrams. Phenotypic characters of morphology and physiology are not diagnostic, but statistically significant differences are observed between the molecular siblings. These properties may be drivers of separate evolutionary trends. Trichophyton mentagrophytes represents the ancestral, homothallic cloud of genotypes with a probable geophilic lifestyle, while T. indotineae and T. interdigitale behave as anthropophilic, clonal offshoots. The origin of T. indotineae, which currently causes a significant public health problem, is zoonotic, and its emergence is likely due to widespread misuse of antifungals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichophyton Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichophyton Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article