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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS.
Jourdain, Alexis A; Begg, Bridget E; Mick, Eran; Shah, Hardik; Calvo, Sarah E; Skinner, Owen S; Sharma, Rohit; Blue, Steven M; Yeo, Gene W; Burge, Christopher B; Mootha, Vamsi K.
Afiliação
  • Jourdain AA; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: alexis.jourdain@
  • Begg BE; Department of Biology, MIT, Cambridge, MA 02139, USA.
  • Mick E; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Shah H; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Calvo SE; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Skinner OS; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sharma R; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Blue SM; Department of Cellular and Molecular Medicine, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Yeo GW; Department of Cellular and Molecular Medicine, Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Burge CB; Department of Biology, MIT, Cambridge, MA 02139, USA.
  • Mootha VK; Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: vamsi@hms.harvar
Mol Cell ; 81(9): 1905-1919.e12, 2021 05 06.
Article em En | MEDLINE | ID: mdl-33852893

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / RNA Mensageiro / Precursores de RNA / Splicing de RNA / Proteínas de Ligação a RNA / Ribonucleoproteína Nuclear Pequena U1 / Glicólise Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / RNA Mensageiro / Precursores de RNA / Splicing de RNA / Proteínas de Ligação a RNA / Ribonucleoproteína Nuclear Pequena U1 / Glicólise Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article