2-Oxaspiro[4.5]decane and α-pyrenocine derivatives from the endophytic fungus Roussoella sp. PSU-H51.
Nat Prod Res
; 36(19): 4911-4920, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-33853446
ABSTRACT
One new 2-oxaspiro[4.5]decane, roussoellide, and one new α-pyrenocine, 2',3'-dihydropyrenocine A, together with nine known compounds including known arthropsolide A, and pyrenocines A and E, were obtained from the culture broth of the endophytic fungus Roussoella sp. Their structures were determined using spectroscopic data. The absolute configuration of known arthropsolide A was assigned on the basis of X-ray diffraction data using Cu Kα radiation. Known pyrenocine A displayed weak cytotoxic activity against breast cancer (MCF-7) cells with an IC50 value of 27.1 µM and weak antifungal activity against Microsporum gypseum SH-MU-4 with an MIC value of 615.2 µM.[Formula see text].
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Antifúngicos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article