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Pregnancy outcomes of infertile women with ultrasound-diagnosed adenomyosis for in vitro fertilization and frozen-thawed embryo transfer.
Zhang, Xiu-Ping; Zhang, Yin-Feng; Shi, Rui; Zhang, Yao-Jia; Zhang, Xue-Luo; Hu, Xiao-Mei; Hu, Xin-Yu; Hu, Yuan-Jing.
Afiliação
  • Zhang XP; Tianjin Medical University, Tianjin, 300070, China.
  • Zhang YF; Department of Gynecologic Oncology, Tianjin Central Hospital of Gynecology Obstetrics, No. 156 Sanma Road, Nankai, Tianjin, 300052, China.
  • Shi R; Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, 030013, China.
  • Zhang YJ; Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, 300052, China.
  • Zhang XL; Tianjin Medical University, Tianjin, 300070, China.
  • Hu XM; Tianjin Medical University, Tianjin, 300070, China.
  • Hu XY; Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, 030013, China.
  • Hu YJ; Tianjin Medical University, Tianjin, 300070, China.
Arch Gynecol Obstet ; 304(4): 1089-1096, 2021 10.
Article em En | MEDLINE | ID: mdl-33856541
OBJECTIVE: This study aimed to investigate the effect of ultrasound-diagnosed adenomyosis on assisted pregnancy outcomes, i.e., in vitro fertilization-embryo transfer (IVF-ET). METHODS: This was a retrospective cohort study of 18,568 women who had received their first frozen-thawed ET cycle in Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi and the Reproductive Medicine Center of Tianjin Central Obstetrics and Gynecology Hospital from January 2014 to May 2019. A total of 5,087 patients met the inclusion and exclusion criteria, and they were divided into two groups: adenomyosis with tubal factor infertility (study group, n = 193) and only tubal factor infertility (control group, n = 4894). After a 1:1 propensity score match (caliper value = 0.005), 360 cases were matched in the end. RESULT: There was no statistical difference in the embryo implantation rate, clinical pregnancy rate, or multiple pregnancy rate between the two groups (28.4% vs. 31.7%, 42.2% vs. 42.8%, and 11.7% vs. 12.8%, respectively; P > 0.05). However, the early miscarriage rate in the adenomyosis group was significantly higher than that in the control group (13.3% vs. 5.6%, respectively; P = 0.012). The live birth rate was 22.8% in the women with adenomyosis and was observed to be significantly lower than 33.3% in the control group (P = 0.026). The patients with adenomyosis had a higher incidence of pregnancy complications than those without (4.4% vs. 0.6%, respectively; P = 0.018), but the neonatal birth weight was not related to adenomyosis. CONCLUSION: Women with adenomyosis should be treated as being at high risk of early miscarriage. However, maternal adenomyosis has no effect on the birth weight of the newborn.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenomiose / Infertilidade Feminina Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies Limite: Child / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenomiose / Infertilidade Feminina Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies Limite: Child / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2021 Tipo de documento: Article