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Synthetic lethality-mediated precision oncology via the tumor transcriptome.
Lee, Joo Sang; Nair, Nishanth Ulhas; Dinstag, Gal; Chapman, Lesley; Chung, Youngmin; Wang, Kun; Sinha, Sanju; Cha, Hongui; Kim, Dasol; Schperberg, Alexander V; Srinivasan, Ajay; Lazar, Vladimir; Rubin, Eitan; Hwang, Sohyun; Berger, Raanan; Beker, Tuvik; Ronai, Ze'ev; Hannenhalli, Sridhar; Gilbert, Mark R; Kurzrock, Razelle; Lee, Se-Hoon; Aldape, Kenneth; Ruppin, Eytan.
Afiliação
  • Lee JS; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Next Generation Medicine Lab, Department of Artificial Intelligence & Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419
  • Nair NU; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Dinstag G; Pangea Therapeutics, Ltd., Tel Aviv 6971003, Israel.
  • Chapman L; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Chung Y; Next Generation Medicine Lab, Department of Artificial Intelligence & Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Wang K; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Sinha S; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Cha H; Department of Digital Health & Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Republic of Korea.
  • Kim D; Next Generation Medicine Lab, Department of Artificial Intelligence & Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Schperberg AV; Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Srinivasan A; Research and Innovations Group, Datar Cancer Genetics Limited, Nasik, Maharashtra 422010, India.
  • Lazar V; Worldwide Innovative Network (WIN) Association-WIN Consortium, Villejuif 94801, France.
  • Rubin E; The Center for Evolutionary Genomics and Medicine, Ben-Gurion University of the Negev, Beersheva 8410501, Israel.
  • Hwang S; Department of Pathology, CHA University, CHA Bundang Medical Center, Seongnam 13497, Republic of Korea.
  • Berger R; Cancer Center, Chaim Sheba Medical Center, Tel Hashomer 5262000, Israel.
  • Beker T; Pangea Therapeutics, Ltd., Tel Aviv 6971003, Israel.
  • Ronai Z; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Hannenhalli S; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Gilbert MR; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Kurzrock R; Worldwide Innovative Network (WIN) Association-WIN Consortium, Villejuif 94801, France; Moore Cancer Center, University of California, San Diego, San Diego, CA 92037, USA.
  • Lee SH; Department of Digital Health & Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Samsung Medical Center, Sungkyunkwan University, Seoul 06351, Republic of Korea; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungky
  • Aldape K; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ruppin E; Cancer Data Science Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: eytan.ruppin@nih.gov.
Cell ; 184(9): 2487-2502.e13, 2021 04 29.
Article em En | MEDLINE | ID: mdl-33857424
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Medicina de Precisão / Terapia de Alvo Molecular / Transcriptoma / Mutações Sintéticas Letais / Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Medicina de Precisão / Terapia de Alvo Molecular / Transcriptoma / Mutações Sintéticas Letais / Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article