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Plasma D-dimer : a promising indicator of COVID-19 infection severity or only an acute phase reactant.
Hançerli Törün, Selda; Kaba, Özge; Sari Yanartas, Mehpare; Demirbuga, Asuman; Somer, Ayper; Suleyman, Ayse; Bayramoglu, Zuhal; Mese, Sevim; Agacfidan, Ali.
Afiliação
  • Hançerli Törün S; Division of Pediatric Infectious Diseases, Departmenf of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey - seldahancerli@hotmail.com.
  • Kaba Ö; Division of Pediatric Infectious Diseases, Departmenf of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Sari Yanartas M; Division of Pediatric Infectious Diseases, Departmenf of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Demirbuga A; Division of Pediatric Infectious Diseases, Departmenf of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Somer A; Division of Pediatric Infectious Diseases, Departmenf of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Suleyman A; Department of Pediatric Allergy, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Bayramoglu Z; Department of Pediatric Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Mese S; Department of Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Agacfidan A; Department of Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Article em En | MEDLINE | ID: mdl-33858127
OBJECTIVE: Serum D-dimer levels, as well as other biomarkers related to coagulation, are significantly elevated during severe community acquired pneumonia. The aim of this study is to investigate the utility of plasma D-dimer levels determining the severity of inflammation and prognosis in pediatric patients with COVID-19 infection. METHODS: We retrospectively chart reviewed medical records of pediatric patients (< 18 years of age) admitted to Istanbul Fcaulty of Medicine, Department of Pediatrics Infectious Disease Service between March 11, and June 30, 2020. We collected demographic, clinical, biochemical and radiographic data. RESULTS: A hundred and seventy-one pediatric patients (1 - 216 months of age) admitted to pediatric infecitous disease service included in this study. Patients were classified into 4 categories; 1) COVID-19 infection confirmed by PCR, 2) Suspected COVID-19 infection due to close exposure history and radiographic findings, 3) Lower respiratory tract infection other than COVID-19 confirmed with multiplex respiratory viral panel, and 4) Systemic infections other than lower respiratory tract infection. Lymphopenia was observed significantly higher in patients with COVID-19 infection compared to patients with other respiratory viral infections (p=0.06). In patients with radiographic findings concerning for COVID-19 infection, elevated serum D-dimer levels were detected significantly higher than lymphopenia (p=0.07). CONCLUSIONS: Elevated serum D-dimer levels at baseline are associated with inflammation especially in patients with COVID-19 infection with radipgraphic findings. Monitoring serum D-dimer levels may be used for early identification of severe cases in children.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article