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A new trick for an old dog? Myocardial-specific roles for prostaglandins as mediators of ischemic injury and repair.
Martens, Matthew D; Fernando, Amy S; Gordon, Joseph W.
Afiliação
  • Martens MD; Department of Human Anatomy and Cell Science, Rady Faculty of Health Science, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Fernando AS; The Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
  • Gordon JW; The Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Am J Physiol Heart Circ Physiol ; 320(6): H2169-H2184, 2021 06 01.
Article em En | MEDLINE | ID: mdl-33861147
The small lipid-derived paracrine signaling molecules known as prostaglandins have been recognized for their ability to modulate many facets of cardiovascular physiology since their initial discovery more than 85 years ago. Although the role of prostaglandins in the vasculature has gained significant attention across time, a handful of historical studies have also directly implicated the cardiomyocyte in both prostaglandin synthesis and release. Recently, our understanding of how prostaglandin receptor modulation impacts and contributes to myocardial structure and function has gained attention while leaving most other components of myocardial prostaglandin metabolism and signaling unexplored. This mini-review highlights both the key historical studies that underpin modern prostaglandin research in the heart, while concurrently presenting the latest findings related to how prostaglandin metabolism and signaling impact myocardial injury and repair.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prostaglandinas / Isquemia Miocárdica / Miócitos Cardíacos / Receptores de Prostaglandina E Subtipo EP3 / Receptores de Prostaglandina E Subtipo EP4 / Miocárdio Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prostaglandinas / Isquemia Miocárdica / Miócitos Cardíacos / Receptores de Prostaglandina E Subtipo EP3 / Receptores de Prostaglandina E Subtipo EP4 / Miocárdio Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article