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Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.
Krishna, Chirag; DiNatale, Renzo G; Kuo, Fengshen; Srivastava, Raghvendra M; Vuong, Lynda; Chowell, Diego; Gupta, Sounak; Vanderbilt, Chad; Purohit, Tanaya A; Liu, Ming; Kansler, Emily; Nixon, Briana G; Chen, Ying-Bei; Makarov, Vladimir; Blum, Kyle A; Attalla, Kyrollis; Weng, Stanley; Salmans, Michael L; Golkaram, Mahdi; Liu, Li; Zhang, Shile; Vijayaraghavan, Raakhee; Pawlowski, Traci; Reuter, Victor; Carlo, Maria I; Voss, Martin H; Coleman, Jonathan; Russo, Paul; Motzer, Robert J; Li, Ming O; Leslie, Christina S; Chan, Timothy A; Hakimi, A Ari.
Afiliação
  • Krishna C; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • DiNatale RG; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, N
  • Kuo F; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Srivastava RM; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Vuong L; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Chowell D; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Gupta S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Vanderbilt C; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Purohit TA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Liu M; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kansler E; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Nixon BG; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
  • Chen YB; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Makarov V; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Blum KA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, N
  • Attalla K; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Weng S; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Salmans ML; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.
  • Golkaram M; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.
  • Liu L; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.
  • Zhang S; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.
  • Vijayaraghavan R; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.
  • Pawlowski T; Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.
  • Reuter V; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Carlo MI; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, NY 10065, USA.
  • Voss MH; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, NY 10065, USA.
  • Coleman J; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Russo P; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Motzer RJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, NY 10065, USA.
  • Li MO; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Leslie CS; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: cleslie@cbio.mskcc.org.
  • Chan TA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Cleveland, OH
  • Hakimi AA; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: hakimia@mskcc.org.
Cancer Cell ; 39(5): 662-677.e6, 2021 05 10.
Article em En | MEDLINE | ID: mdl-33861994
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Carcinoma de Células Renais / Linfócitos T / Neoplasias Renais Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Carcinoma de Células Renais / Linfócitos T / Neoplasias Renais Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article