Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) family.

Fang, Lincheng; Hu, Zhaoxue; Yang, Yifei; Chen, Pan; Zhou, Jinpei; Zhang, Huibin

Fang, Lincheng; Hu, Zhaoxue; Yang, Yifei; Chen, Pan; Zhou, Jinpei; Zhang, Huibin.

Afiliação

Fang L; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Hu Z; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China.
Yang Y; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Chen P; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
Zhou J; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: jpzhou668@163.com.
Zhang H; Center for Drug Discovery, Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: zhanghb80@163.com.

Bioorg Med Chem ; 39: 116133, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33862375

Assuntos

Antineoplásicos/farmacologia; Proteínas de Ciclo Celular/antagonistas & inibidores; Descoberta de Drogas; Fatores de Transcrição/antagonistas & inibidores; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Concentração Inibidora 50; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

BET inhibitors; Biological mechanism; Molecular docking; Multiple myeloma (MM)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas de Ciclo Celular / Descoberta de Drogas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google