A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice.

Fraga, Daiane B; Camargo, Anderson; Olescowicz, Gislaine; Azevedo Padilha, Dayane; Mina, Francielle; Budni, Josiane; Brocardo, Patricia S; Rodrigues, Ana Lúcia S

Fraga, Daiane B; Camargo, Anderson; Olescowicz, Gislaine; Azevedo Padilha, Dayane; Mina, Francielle; Budni, Josiane; Brocardo, Patricia S; Rodrigues, Ana Lúcia S.

Afiliação

Fraga DB; Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Camargo A; Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Olescowicz G; Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Azevedo Padilha D; Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Mina F; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.
Budni J; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciúma, SC, Brazil.
Brocardo PS; Department of Morphological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Rodrigues ALS; Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis, SC, Brazil. Electronic address: ana.l.rodrigues@ufsc.br.

Chem Biol Interact ; 342: 109476, 2021 Jun 01.

Article em En | MEDLINE | ID: mdl-33872575

Assuntos

Antidepressivos/uso terapêutico; Ácido Ascórbico/uso terapêutico; Depressão/tratamento farmacológico; Hipocampo/efeitos dos fármacos; Animais; Corticosterona; Espinhas Dendríticas/efeitos dos fármacos; Depressão/induzido quimicamente; Feminino; Elevação dos Membros Posteriores; Ketamina/uso terapêutico; Camundongos; Fármacos Neuroprotetores/uso terapêutico

Palavras-chave

Ascorbic acid; Corticosterone; Dendrite spine; Depression; Ketamine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Depressão / Hipocampo / Antidepressivos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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