Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species.

O'Regan, Grace C; Farag, Sahar H; Casey, Caroline S; Wood-Kaczmar, Alison; Pocock, Jennifer M; Tabrizi, Sarah J; Andre, Ralph

O'Regan, Grace C; Farag, Sahar H; Casey, Caroline S; Wood-Kaczmar, Alison; Pocock, Jennifer M; Tabrizi, Sarah J; Andre, Ralph.

Afiliação

O'Regan GC; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, UK.
Farag SH; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, UK.
Casey CS; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, UK.
Wood-Kaczmar A; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, UK.
Pocock JM; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, WC1N 1PJ, London, UK.
Tabrizi SJ; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, UK. s.tabrizi@ucl.ac.uk.
Andre R; Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG, London, UK. ralph.andre@ucl.ac.uk.

J Neuroinflammation ; 18(1): 94, 2021 Apr 19.

Article em En | MEDLINE | ID: mdl-33874957

Assuntos

Doença de Huntington; Células-Tronco Pluripotentes Induzidas/metabolismo; Células-Tronco Pluripotentes Induzidas/patologia; Microglia/metabolismo; Microglia/patologia; Espécies Reativas de Oxigênio/metabolismo; Diferenciação Celular; Linhagem Celular; Corpo Estriado/metabolismo; Humanos; Proteína Huntingtina/genética; Proteína Huntingtina/metabolismo; Doença de Huntington/genética; Doença de Huntington/metabolismo; Doença de Huntington/patologia; Doença de Huntington/fisiopatologia; Mutação; Neurônios/metabolismo

Palavras-chave

Cytokines; Huntington's disease; Microglia; Neurodegeneration; Pluripotent stem cells; Reactive oxygen species; Striatal neurons

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Doença de Huntington / Microglia / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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