An ultrasound-guided injection method for a syngeneic orthotopic murine model of breast cancer.
Lab Anim
; 55(5): 472-477, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-33884898
ABSTRACT
Breast cancer is the most common cancer among women worldwide. For high-risk women, contrast enhanced (CE)-magnetic resonance imaging (MRI) is recommended as supplemental screening together with mammography. The development of new MRI contrast agents is an active field of research, which requires efficacy tests on appropriate preclinical pathological models. In this work, a refined method to orthotopically induce breast cancer in BALB/c mice was developed using ultrasound (US) as a guide for the precise localisation of the tumour induction site and to improve animal welfare. The method was coupled with CE-MRI to characterise the evolution of the tumoural lesion.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mamografia
/
Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article