Detecting beta-amyloid glycation by intrinsic fluorescence - Understanding the link between diabetes and Alzheimer's disease.
Arch Biochem Biophys
; 704: 108886, 2021 06 15.
Article
em En
| MEDLINE
| ID: mdl-33887256
ABSTRACT
We monitor early stages of beta-amyloid (Aß1-40) aggregation, one of the key processes leading to Alzheimer's disease (AD), in the presence of high glucose concentrations by measuring Aß1- 40 intrinsic fluorescence. The multiple peaks and their shifts observed in the time-resolved emission spectra (TRES) reveal the impact of glycation on Aß1- 40 oligomerisation. The results show that formation of the advanced glycation end products (AGEs) alters the aggregation pathway. These changes are highly relevant to our understanding of the pathophysiology of AD and the implication of AGE and diabetes in these pathways.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Peptídeos beta-Amiloides
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Diabetes Mellitus
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Multimerização Proteica
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Doença de Alzheimer
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article