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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
Harris, William S; Tintle, Nathan L; Imamura, Fumiaki; Qian, Frank; Korat, Andres V Ardisson; Marklund, Matti; Djoussé, Luc; Bassett, Julie K; Carmichael, Pierre-Hugues; Chen, Yun-Yu; Hirakawa, Yoichiro; Küpers, Leanne K; Laguzzi, Federica; Lankinen, Maria; Murphy, Rachel A; Samieri, Cécilia; Senn, Mackenzie K; Shi, Peilin; Virtanen, Jyrki K; Brouwer, Ingeborg A; Chien, Kuo-Liong; Eiriksdottir, Gudny; Forouhi, Nita G; Geleijnse, Johanna M; Giles, Graham G; Gudnason, Vilmundur; Helmer, Catherine; Hodge, Allison; Jackson, Rebecca; Khaw, Kay-Tee; Laakso, Markku; Lai, Heidi; Laurin, Danielle; Leander, Karin; Lindsay, Joan; Micha, Renata; Mursu, Jaako; Ninomiya, Toshiharu; Post, Wendy; Psaty, Bruce M; Risérus, Ulf; Robinson, Jennifer G; Shadyab, Aladdin H; Snetselaar, Linda; Sala-Vila, Aleix; Sun, Yangbo; Steffen, Lyn M; Tsai, Michael Y; Wareham, Nicholas J; Wood, Alexis C.
Afiliação
  • Harris WS; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA. wsh@faresinst.com.
  • Tintle NL; The Fatty Acid Research Institute, Sioux Falls, SD, USA. wsh@faresinst.com.
  • Imamura F; The Fatty Acid Research Institute, Sioux Falls, SD, USA.
  • Qian F; Department of Mathematics and Statistics, Dordt University, Sioux Center, IA, USA.
  • Korat AVA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Marklund M; Department of Nutrition, Harvard T.H. Chan School of Public Health and Harvard Medical School, Boston, MA, USA.
  • Djoussé L; Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
  • Bassett JK; Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
  • Carmichael PH; The George Institute for Global Health and the Faculty of Medicine, University New South Wales, Sydney, Australia.
  • Chen YY; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Hirakawa Y; Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
  • Küpers LK; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
  • Laguzzi F; Centre D'excellence Sur le Vieillissement de Québec, CIUSSS-CN, Quebec, QC, Canada.
  • Lankinen M; Department of Medicine, Taipei Veterans General Hospital; and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
  • Murphy RA; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Samieri C; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
  • Senn MK; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
  • Shi P; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Virtanen JK; Cancer Control Research, BC Cancer Agency; and School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
  • Brouwer IA; Bordeaux Population Health Research Centre, INSERM, University of Bordeaux, Bordeaux, France.
  • Chien KL; USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA.
  • Eiriksdottir G; Freidman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
  • Forouhi NG; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Geleijnse JM; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam and Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
  • Giles GG; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
  • Gudnason V; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Helmer C; Icelandic Heart Association, Kopavogur, Iceland.
  • Hodge A; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Jackson R; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
  • Khaw KT; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia.
  • Laakso M; Icelandic Heart Association, Kopavogur, Iceland.
  • Lai H; School of Health Sciences, University of Iceland, Reykjavík, Iceland.
  • Laurin D; Bordeaux Population Health Research Centre, INSERM, University of Bordeaux, Bordeaux, France.
  • Leander K; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Australia.
  • Lindsay J; Department of Internal Medicine, Division of Endocrinology, The Ohio State University, Columbus, OH, USA.
  • Micha R; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Mursu J; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  • Ninomiya T; Freidman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
  • Post W; Department of Primary Care and Public Health, Imperial College, London, UK.
  • Psaty BM; Centre D'excellence Sur le Vieillissement de Québec, CIUSSS-CN, Quebec, QC, Canada.
  • Risérus U; VITAM Research Centers, Laval University, Quebec, QC, Canada.
  • Robinson JG; Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
  • Shadyab AH; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.
  • Snetselaar L; Freidman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
  • Sala-Vila A; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Sun Y; Department of Epidemiology and Public Health, Kyushu University, Fukuoka, Japan.
  • Steffen LM; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
  • Tsai MY; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Wareham NJ; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
  • Wood AC; Department of Medicine, University of Iowa, Iowa City, IA, USA.
Nat Commun ; 12(1): 2329, 2021 04 22.
Article em En | MEDLINE | ID: mdl-33888689
ABSTRACT
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Ômega-3 / Causas de Morte / Mortalidade Prematura Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Graxos Ômega-3 / Causas de Morte / Mortalidade Prematura Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article