The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on &#945;-dystroglycan.

Imae, Rieko; Kuwabara, Naoyuki; Manya, Hiroshi; Tanaka, Tomohiro; Tsuyuguchi, Masato; Mizuno, Mamoru; Endo, Tamao; Kato, Ryuichi

The structure of POMGNT2 provides new insights into the mechanism to determine the functional O-mannosylation site on α-dystroglycan.

Imae, Rieko; Kuwabara, Naoyuki; Manya, Hiroshi; Tanaka, Tomohiro; Tsuyuguchi, Masato; Mizuno, Mamoru; Endo, Tamao; Kato, Ryuichi.

Afiliação

Imae R; Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Japan.
Kuwabara N; High Energy Accelerator Research Organization (KEK), Institute of Materials Structure Science, Structural Biology Research Center, Tsukuba, Japan.
Manya H; Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Japan.
Tanaka T; Laboratory of Glyco-organic Chemistry, The Noguchi Institute, Itabashi-ku, Japan.
Tsuyuguchi M; High Energy Accelerator Research Organization (KEK), Institute of Materials Structure Science, Structural Biology Research Center, Tsukuba, Japan.
Mizuno M; Laboratory of Glyco-organic Chemistry, The Noguchi Institute, Itabashi-ku, Japan.
Endo T; Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi-ku, Japan.
Kato R; High Energy Accelerator Research Organization (KEK), Institute of Materials Structure Science, Structural Biology Research Center, Tsukuba, Japan.

Genes Cells ; 26(7): 485-494, 2021 Jul.

Article em En | MEDLINE | ID: mdl-33893702

Assuntos

Domínio Catalítico; Glicosiltransferases/química; Distroglicanas/metabolismo; Glicosiltransferases/metabolismo; Humanos; Manose/metabolismo; Ligação Proteica

Palavras-chave

core M3; fibronectin type III domain; glycosyltransferase; muscular dystrophy; α-dystroglycanopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosiltransferases / Domínio Catalítico Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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