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Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Yan, Nicholas L; Santos-Martins, Diogo; Nair, Reji; Chu, Alan; Wilson, Ian A; Johnson, Kristen A; Forli, Stefano; Morgan, Gareth J; Petrassi, H Michael; Kelly, Jeffery W.
Afiliação
  • Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
  • Santos-Martins D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
  • Nair R; Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.
  • Chu A; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
  • Johnson KA; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States.
  • Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
  • Morgan GJ; Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, United States.
  • Petrassi HM; The Amyloidosis Center, Boston University School of Medicine, Boston, Massachusetts 02118, United States.
  • Kelly JW; California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States.
J Med Chem ; 64(9): 6273-6299, 2021 05 13.
Article em En | MEDLINE | ID: mdl-33939422
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Cadeias Leves de Imunoglobulina / Cumarínicos / Amiloide Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Cadeias Leves de Imunoglobulina / Cumarínicos / Amiloide Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article