Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer's disease.

Tsuji, Shingo; Hase, Takeshi; Yachie-Kinoshita, Ayako; Nishino, Taiko; Ghosh, Samik; Kikuchi, Masataka; Shimokawa, Kazuro; Aburatani, Hiroyuki; Kitano, Hiroaki; Tanaka, Hiroshi

Tsuji, Shingo; Hase, Takeshi; Yachie-Kinoshita, Ayako; Nishino, Taiko; Ghosh, Samik; Kikuchi, Masataka; Shimokawa, Kazuro; Aburatani, Hiroyuki; Kitano, Hiroaki; Tanaka, Hiroshi.

Afiliação

Tsuji S; Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. tsuji@genome.rcast.u-tokyo.ac.jp.
Hase T; The Systems Biology Institute, Saisei Ikedayama Bldg. 5-10-25 Higashi Gotanda Shinagawa, Tokyo, 141-0022, Japan.
Yachie-Kinoshita A; Institute of Education, Tokyo Medical and Dental University, 20F, M&D Tower, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
Nishino T; SBX BioSciences, Inc, 1600 - 925 West Georgia Street, Vancouver, BC V6C 3L2, Canada.
Ghosh S; Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan.
Kikuchi M; The Systems Biology Institute, Saisei Ikedayama Bldg. 5-10-25 Higashi Gotanda Shinagawa, Tokyo, 141-0022, Japan.
Shimokawa K; SBX BioSciences, Inc, 1600 - 925 West Georgia Street, Vancouver, BC V6C 3L2, Canada.
Aburatani H; The Systems Biology Institute, Saisei Ikedayama Bldg. 5-10-25 Higashi Gotanda Shinagawa, Tokyo, 141-0022, Japan.
Kitano H; The Systems Biology Institute, Saisei Ikedayama Bldg. 5-10-25 Higashi Gotanda Shinagawa, Tokyo, 141-0022, Japan.
Tanaka H; Department of Genome Informatics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Alzheimers Res Ther ; 13(1): 92, 2021 05 03.

Article em En | MEDLINE | ID: mdl-33941241

Assuntos

Doença de Alzheimer; Preparações Farmacêuticas; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Inteligência Artificial; Reposicionamento de Medicamentos; Humanos; Aprendizado de Máquina

Palavras-chave

Deep learning; Drug discovery; Machine learning; Network embedding; Protein interaction network; Systems biology

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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