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Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.
D'Andrea, Laura; Lucato, Christina M; Marquez, Elsa A; Chang, Yong-Gang; Civciristov, Srgjan; Mastos, Chantel; Lupton, Christopher J; Huang, Cheng; Elmlund, Hans; Schittenhelm, Ralf B; Mitchell, Christina A; Whisstock, James C; Halls, Michelle L; Ellisdon, Andrew M.
Afiliação
  • D'Andrea L; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Lucato CM; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Marquez EA; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Chang YG; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Civciristov S; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia.
  • Mastos C; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052 Victoria, Australia.
  • Lupton CJ; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Huang C; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Elmlund H; Monash Proteomics & Metabolomics Facility, Monash University, Clayton, 3800 Victoria, Australia.
  • Schittenhelm RB; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Mitchell CA; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Whisstock JC; Monash Proteomics & Metabolomics Facility, Monash University, Clayton, 3800 Victoria, Australia.
  • Halls ML; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
  • Ellisdon AM; Biomedicine Discovery Institute, Monash University, Clayton, 3800 Victoria, Australia.
Sci Signal ; 14(681)2021 05 04.
Article em En | MEDLINE | ID: mdl-33947796
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas rac1 de Ligação ao GTP / Fatores de Troca do Nucleotídeo Guanina / PTEN Fosfo-Hidrolase / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas rac1 de Ligação ao GTP / Fatores de Troca do Nucleotídeo Guanina / PTEN Fosfo-Hidrolase / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article