Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR-Based Functional Screening of Osteoporosis Candidate Genes.

Bek, Jan Willem; Shochat, Chen; De Clercq, Adelbert; De Saffel, Hanna; Boel, Annekatrien; Metz, Juriaan; Rodenburg, Frans; Karasik, David; Willaert, Andy; Coucke, Paul J

Bek, Jan Willem; Shochat, Chen; De Clercq, Adelbert; De Saffel, Hanna; Boel, Annekatrien; Metz, Juriaan; Rodenburg, Frans; Karasik, David; Willaert, Andy; Coucke, Paul J.

Afiliação

Bek JW; Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Shochat C; The Musculoskeletal Genetics Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
De Clercq A; Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
De Saffel H; Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Boel A; Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Metz J; Department for Reproductive Medicine, Ghent University-University Hospital, Ghent, Belgium.
Rodenburg F; Department of Animal Ecology and Physiology, Radboud University, Nijmegen, The Netherlands.
Karasik D; School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.
Willaert A; Institute of Biology, Leiden University, Leiden, The Netherlands.
Coucke PJ; Mathematical Institute, Leiden University, Leiden, The Netherlands.

J Bone Miner Res ; 36(9): 1749-1764, 2021 09.

Article em En | MEDLINE | ID: mdl-33957005

Assuntos

Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade; Osteoporose; Peixe-Zebra; Animais; Densidade Óssea; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; Modelos Animais de Doenças; Humanos; Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética; Osteoporose/diagnóstico por imagem; Osteoporose/genética; Genética Reversa; Via de Sinalização Wnt; Microtomografia por Raio-X; Peixe-Zebra/genética

Palavras-chave

BONE QCT/µCT; GENETIC ANIMAL MODELS; OSTEOPOROSIS; WNT/Β-CATENIN/LRPS

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Peixe-Zebra / Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google