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Human cells and networks of pain: Transforming pain target identification and therapeutic development.
Renthal, William; Chamessian, Alexander; Curatolo, Michele; Davidson, Steve; Burton, Michael; Dib-Hajj, Sulayman; Dougherty, Patrick M; Ebert, Allison D; Gereau, Robert W; Ghetti, Andre; Gold, Michael S; Hoben, Gwendolyn; Menichella, Daniela Maria; Mercier, Philippe; Ray, Wilson Z; Salvemini, Daniela; Seal, Rebecca P; Waxman, Stephen; Woolf, Clifford J; Stucky, Cheryl L; Price, Theodore J.
Afiliação
  • Renthal W; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: wrenthal@bwh.harvard.edu.
  • Chamessian A; Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Curatolo M; Department of Anesthesiology and Pain Medicine, CLEAR Center for Musculoskeletal Disorder, Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA 98195, USA.
  • Davidson S; Department of Anesthesiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
  • Burton M; Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA.
  • Dib-Hajj S; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
  • Dougherty PM; Department of Pain Medicine, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX 78712, USA.
  • Ebert AD; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Gereau RW; Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St Louis, MO 63110, USA.
  • Ghetti A; AnaBios Corporation, San Diego, CA 92109, USA.
  • Gold MS; Department of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Hoben G; Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Menichella DM; Department of Neurology and Pharmacology, Northwestern University Feinberg Medical School, Chicago, IL 60611, USA.
  • Mercier P; Department of Neurosurgery and Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO 63117, USA.
  • Ray WZ; Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Salvemini D; Department of Pharmacology and Physiology and Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO 63103, USA.
  • Seal RP; Department of Neurobiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Waxman S; Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT 06516, USA.
  • Woolf CJ; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Stucky CL; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address: cstucky@mcw.edu.
  • Price TJ; Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX 75080, USA. Electronic address: theodore.price@utdallas.edu.
Neuron ; 109(9): 1426-1429, 2021 05 05.
Article em En | MEDLINE | ID: mdl-33957072
ABSTRACT
Chronic pain is a disabling disease with limited treatment options. While animal models have revealed important aspects of pain neurobiology, therapeutic translation of this knowledge requires our understanding of these cells and networks of pain in humans. We propose a multi-institutional collaboration to rigorously and ethically address this challenge.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colaboração Intersetorial / Dor Crônica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colaboração Intersetorial / Dor Crônica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article