Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.
Phytochemistry
; 187: 112705, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-33957541
Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11â¯cell with IC50 values of 3.94⯱â¯0.06⯵M and 3.87⯱â¯0.10⯵M, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48⯱â¯0.06⯵M and 7.88⯱â¯0.60⯵M, respectively.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Ferula
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article