Increased RET Activity Coupled with a Reduction in the <i>RET</i> Gene Dosage Causes Intestinal Aganglionosis in Mice.

Okamoto, Mitsumasa; Uesaka, Toshihiro; Ito, Keisuke; Enomoto, Hideki

Increased RET Activity Coupled with a Reduction in the RET Gene Dosage Causes Intestinal Aganglionosis in Mice.

Okamoto, Mitsumasa; Uesaka, Toshihiro; Ito, Keisuke; Enomoto, Hideki.

Afiliação

Okamoto M; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Uesaka T; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Ito K; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Enomoto H; Division for Neural Differentiation and Regeneration, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan enomotoh@med.kobe-u.ac.jp.

eNeuro ; 8(3)2021.

Article em En | MEDLINE | ID: mdl-33958373

Assuntos

Doença de Hirschsprung; Proteínas Proto-Oncogênicas c-ret; Animais; Dosagem de Genes; Fator Neurotrófico Derivado de Linhagem de Célula Glial/genética; Doença de Hirschsprung/genética; Humanos; Camundongos; Mutação/genética; Proteínas Proto-Oncogênicas c-ret/genética

Palavras-chave

Hirschsprung's disease; RET; cell signaling; enteric nervous system; neuronal differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-ret / Doença de Hirschsprung Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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