Heparanase overexpression impedes perivascular clearance of amyloid-ß from murine brain: relevance to Alzheimer's disease.

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Yingxia; Zhang, Ganlin; Barash, Uri; Wang, Xiaomin; Lannfelt, Lars; Vlodavsky, Israel; Lindahl, Ulf; Li, Jin-Ping

Zhang, Xiao; O'Callaghan, Paul; Li, Honglian; Tan, Yingxia; Zhang, Ganlin; Barash, Uri; Wang, Xiaomin; Lannfelt, Lars; Vlodavsky, Israel; Lindahl, Ulf; Li, Jin-Ping.

Afiliação

Zhang X; Department of Neuroscience, Pharmacogly, University of Uppsala, The Biomedical Center Husargatan 3, Box 593, 751 23, Uppsala, Sweden.
O'Callaghan P; Department of Medical Cell Biology, University of Uppsala, The Biomedical Center Husargatan 3, Box 571, 751 23, Uppsala, Sweden.
Li H; Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, University of Uppsala, The Biomedical Center Husargatan 3, Box 582, 751 23, Uppsala, Sweden.
Tan Y; Stem Cell and Regenerative Medicine Lab, Institute of Health Service and Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
Zhang G; Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, University of Uppsala, The Biomedical Center Husargatan 3, Box 582, 751 23, Uppsala, Sweden.
Barash U; Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, University of Uppsala, The Biomedical Center Husargatan 3, Box 582, 751 23, Uppsala, Sweden.
Wang X; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23, Back Road of Art Gallery, Beijing, 100010, China.
Lannfelt L; Cancer and Vascular Biology Research Center, The Rappaport Faculty of Medicine, 31096, Technion, Haifa, Israel.
Vlodavsky I; Department of Medical Biochemistry and Microbiology, SciLifeLab Uppsala, University of Uppsala, The Biomedical Center Husargatan 3, Box 582, 751 23, Uppsala, Sweden.
Lindahl U; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23, Back Road of Art Gallery, Beijing, 100010, China.
Li JP; Department of Public Health and Caring Sciences, Rudbeck Laboratory, University of Uppsala, Molecular Geriatrics Dag Hammarskjölds väg 20, 751 85, Uppsala, Sweden.

Acta Neuropathol Commun ; 9(1): 84, 2021 05 10.

Article em En | MEDLINE | ID: mdl-33971986

Assuntos

Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Encéfalo/metabolismo; Regulação Enzimológica da Expressão Gênica; Glucuronidase/biossíntese; Sistema Glinfático/metabolismo; Idoso de 80 Anos ou mais; Doença de Alzheimer/genética; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/administração & dosagem; Peptídeos beta-Amiloides/genética; Peptídeos beta-Amiloides/toxicidade; Animais; Encéfalo/patologia; Feminino; Glucuronidase/genética; Sistema Glinfático/patologia; Humanos; Injeções Intraventriculares; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Fragmentos de Peptídeos/administração & dosagem; Fragmentos de Peptídeos/toxicidade

Palavras-chave

Aging; Alzheimer's disease; Amyloid-ß; Clearance; Heparan sulfate; Heparanase; Perivascular drainage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Regulação Enzimológica da Expressão Gênica / Peptídeos beta-Amiloides / Doença de Alzheimer / Sistema Glinfático / Glucuronidase Limite: Aged80 / Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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