GABAergic synapses suppress intestinal innate immunity via insulin signaling in <i>Caenorhabditis elegans</i>.

Zheng, Zhongfan; Zhang, Xiumei; Liu, Junqiang; He, Ping; Zhang, Shan; Zhang, Yongning; Gao, Jie; Yang, Shengmei; Kang, Na; Afridi, Muhammad Irfan; Gao, Shangbang; Chen, Chunhong; Tu, Haijun

GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.

Zheng, Zhongfan; Zhang, Xiumei; Liu, Junqiang; He, Ping; Zhang, Shan; Zhang, Yongning; Gao, Jie; Yang, Shengmei; Kang, Na; Afridi, Muhammad Irfan; Gao, Shangbang; Chen, Chunhong; Tu, Haijun.

Afiliação

Zheng Z; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Zhang X; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Liu J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
He P; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Zhang S; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Zhang Y; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China.
Gao J; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Yang S; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Kang N; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Afridi MI; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Gao S; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, China.
Chen C; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, 410082 Changsha, China.
Tu H; Shenzhen Research Institute, Hunan University, 518000 Shenzhen, China.

Proc Natl Acad Sci U S A ; 118(20)2021 05 18.

Article em En | MEDLINE | ID: mdl-33972423

Assuntos

Proteínas de Caenorhabditis elegans/imunologia; Caenorhabditis elegans/imunologia; Imunidade Inata/imunologia; Insulina/imunologia; Intestinos/imunologia; Receptores de GABA-A/imunologia; Sinapses/imunologia; Adulto; Animais; Caenorhabditis elegans/genética; Caenorhabditis elegans/microbiologia; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/fisiologia; Neurônios GABAérgicos/imunologia; Neurônios GABAérgicos/metabolismo; Neurônios GABAérgicos/microbiologia; Interações Hospedeiro-Patógeno/imunologia; Humanos; Imunidade Inata/genética; Insulina/metabolismo; Intestinos/microbiologia; Intestinos/fisiologia; Mutação; Junção Neuromuscular/imunologia; Junção Neuromuscular/microbiologia; Junção Neuromuscular/fisiologia; Pseudomonas aeruginosa/imunologia; Pseudomonas aeruginosa/fisiologia; Receptores de GABA-A/genética; Receptores de GABA-A/fisiologia; Transdução de Sinais/imunologia; Sinapses/microbiologia; Sinapses/fisiologia; Transmissão Sináptica/genética; Transmissão Sináptica/imunologia; Transmissão Sináptica/fisiologia

Palavras-chave

GABAergic synapse; innate immunity; insulin signaling; intestine; muscle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinapses / Caenorhabditis elegans / Receptores de GABA-A / Proteínas de Caenorhabditis elegans / Imunidade Inata / Insulina / Intestinos Limite: Adult / Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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