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Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
Teng, Kai Wen; Tsai, Steven T; Hattori, Takamitsu; Fedele, Carmine; Koide, Akiko; Yang, Chao; Hou, Xuben; Zhang, Yingkai; Neel, Benjamin G; O'Bryan, John P; Koide, Shohei.
Afiliação
  • Teng KW; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
  • Tsai ST; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
  • Hattori T; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
  • Fedele C; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.
  • Koide A; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
  • Yang C; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
  • Hou X; Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
  • Zhang Y; Department of Chemistry, New York University, New York, NY, USA.
  • Neel BG; Department of Chemistry, New York University, New York, NY, USA.
  • O'Bryan JP; Department of Chemistry, New York University, New York, NY, USA.
  • Koide S; Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Nat Commun ; 12(1): 2656, 2021 05 11.
Article em En | MEDLINE | ID: mdl-33976200
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Ensaios Antitumorais Modelo de Xenoenxerto / Proteínas Mutantes / Anticorpos Monoclonais / Mutação / Neoplasias Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Ensaios Antitumorais Modelo de Xenoenxerto / Proteínas Mutantes / Anticorpos Monoclonais / Mutação / Neoplasias Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article