Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.
J Med Chem
; 64(11): 7272-7274, 2021 06 10.
Article
em En
| MEDLINE
| ID: mdl-33988992
ABSTRACT
Halogenated phenazines (HPs) are potent antimicrobial agents. A newly developed halogenated phenazine, HP-29, displays remarkable minimum inhibitory concentration (MIC) of 0.08 µM against methicillin-resistant Staphylococcus aureus, MRSA. HP-29 eradicates preformed biofilm via iron starvation, is nontoxic to mammalian cell lines and is efficacious in wound infection models.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biofilmes
/
Ferro
/
Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article