Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-Î³-Shh-BDNF pathway.

Wang, Ge; Zhang, Hongyang; Sun, Jiancong; Zhang, Yuwei; He, Fen; Zou, Juntao

Wang, Ge; Zhang, Hongyang; Sun, Jiancong; Zhang, Yuwei; He, Fen; Zou, Juntao.

Afiliação

Wang G; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China; Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 200032 Shanghai, People's Republic of China.
Zhang H; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Sun J; Department of Radiation Oncology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Zhang Y; Department of Anatomy, Wannan Medical College, Wuhu, Anhui, People's Republic of China.
He F; Department of Radiation Oncology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China. Electronic address: myrahefen@163.com.
Zou J; Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. Electronic address: zoujunt@mail.sysu.edu.cn.

Int Immunopharmacol ; 96: 107744, 2021 Jul.

Article em En | MEDLINE | ID: mdl-33993101

Assuntos

Fator Neurotrófico Derivado do Encéfalo/metabolismo; Transtornos Cognitivos/induzido quimicamente; Ciclosporina/toxicidade; Proteínas Hedgehog/metabolismo; Hipocampo/efeitos dos fármacos; Interferon gama/metabolismo; Animais; Animais Recém-Nascidos; Fator Neurotrófico Derivado do Encéfalo/genética; Transtornos Cognitivos/metabolismo; Transtornos Cognitivos/patologia; Modelos Animais de Doenças; Proteínas Hedgehog/genética; Hipocampo/imunologia; Hipocampo/patologia; Imunossupressores/toxicidade; Interferon gama/genética; Camundongos; Camundongos Endogâmicos C57BL; Neurogênese; Transdução de Sinais

Palavras-chave

BDNF; Cognitive function; Cyclosporin A; IFN-Î³; Neurogenesis; Shh signaling pathway

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon gama / Ciclosporina / Transtornos Cognitivos / Fator Neurotrófico Derivado do Encéfalo / Proteínas Hedgehog / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google