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Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: ß-oxidation as a potential augmenting pathway for inhibition.
Kowalski, John P; Pelletier, Robert D; McDonald, Matthew G; Kelly, Edward J; Rettie, Allan E.
Afiliação
  • Kowalski JP; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA.
  • Pelletier RD; Department of Drug Metabolism and Pharmacokinetics, Pfizer Boulder R&D, Boulder, CO, USA.
  • McDonald MG; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA.
  • Kelly EJ; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA.
  • Rettie AE; Department of Drug Metabolism and Pharmacokinetics, Pfizer Boulder R&D, Boulder, CO, USA.
Xenobiotica ; 51(8): 901-915, 2021 Aug.
Article em En | MEDLINE | ID: mdl-33993844
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Sistema Enzimático do Citocromo P-450 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Sistema Enzimático do Citocromo P-450 Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article