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Genetically blocking HPD via CRISPR-Cas9 protects against lethal liver injury in a pig model of tyrosinemia type I.
Gu, Peng; Yang, Qin; Chen, Bangzhu; Bie, Ya-Nan; Liu, Wen; Tian, Yuguang; Luo, Hongquan; Xu, Tao; Liang, Chunjin; Ye, Xing; Liu, Yan; Tang, Xiangwu; Gu, Weiwang.
Afiliação
  • Gu P; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Yang Q; School of Basic Medical Science, Southern Medical University, Guangzhou 510515, China.
  • Chen B; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Bie YN; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Liu W; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Tian Y; School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
  • Luo H; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Xu T; Department of Animal Science, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.
  • Liang C; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Ye X; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Liu Y; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Tang X; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
  • Gu W; Institute of Comparative Medicine & Laboratory Animal Management Center, Southern Medical University, Guangzhou 510515, China.
Mol Ther Methods Clin Dev ; 21: 530-547, 2021 Jun 11.
Article em En | MEDLINE | ID: mdl-33997102
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article