Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft.
J Mater Sci Mater Med
; 32(6): 60, 2021 May 17.
Article
em En
| MEDLINE
| ID: mdl-33999295
ABSTRACT
The process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatos
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Transplante Ósseo
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Substitutos Ósseos
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Vidro
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article