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Gonadotrophin-independent Precocious Puberty Secondary to an Estrogen Secreting Adrenal Tumor.
Tseretopoulou, Xanthippi; Murray, Matthew J; Buck, Jackie; Hook, C Elizabeth; Jackson, Claire; Kosmoliaptsis, Vasilis; Hughes, Jacqueline; Gorman, Samantha; Williams, Rachel M.
Afiliação
  • Tseretopoulou X; Departments of Pediatric Endocrinology.
  • Murray MJ; Pediatric Haematology and Oncology.
  • Buck J; Department of Pathology, University of Cambridge.
  • Hook CE; Department of Pediatrics, East Suffolk and North Essex NHS Foundation Trust, Essex, UK.
  • Jackson C; Histopathology.
  • Kosmoliaptsis V; Pediatric Surgery.
  • Hughes J; Pediatric Surgery.
  • Gorman S; Radiology, Cambridge University Hospitals NHS Foundation Trust.
  • Williams RM; Departments of Pediatric Endocrinology.
J Pediatr Hematol Oncol ; 44(3): e736-e739, 2022 Apr 01.
Article em En | MEDLINE | ID: mdl-34001797
BACKGROUND: Adrenal masses are rare in children and most commonly present with clinical features of virilization in the absence of activation of the pituitary axis-gonadotrophin-independent precocious puberty. OBSERVATIONS: We report an unusual case of a 7-year-old girl who presented with clinical signs suggestive of exposure to both androgens and estrogens. Imaging revealed a left-sided adrenal mass with no evidence of metastasis. She underwent successful laparoscopic unilateral adrenalectomy. Histology confirmed an adrenal adenoma. CONCLUSION: We conclude that adrenocortical tumors should be considered in children presenting with gonadotrophin-independent precocious puberty and raised estrogens.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Puberdade Precoce / Neoplasias das Glândulas Suprarrenais / Adenoma Adrenocortical Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Child / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Puberdade Precoce / Neoplasias das Glândulas Suprarrenais / Adenoma Adrenocortical Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Child / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article