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Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors*.
Quach, David; Tang, Guanghui; Anantharajan, Jothi; Baburajendran, Nithya; Poulsen, Anders; Wee, John L K; Retna, Priya; Li, Rong; Liu, Boping; Tee, Doris H Y; Kwek, Perlyn Z; Joy, Joma K; Yang, Wan-Qi; Zhang, Chong-Jing; Foo, Klement; Keller, Thomas H; Yao, Shao Q.
Afiliação
  • Quach D; NUS Graduate School for Integrative Sciences and Engineering, 21 Lower Kent Ridge, University Hall, Tan China Tuan Wing, #04-02, Singapore, 119077, Singapore.
  • Tang G; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Anantharajan J; Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
  • Baburajendran N; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Poulsen A; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Wee JLK; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Retna P; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Li R; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Liu B; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Tee DHY; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Kwek PZ; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Joy JK; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Yang WQ; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Zhang CJ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Foo K; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines and Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
  • Keller TH; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
  • Yao SQ; Experimental Drug Development Centre, 10 Biopolis Road, Chromos, #05-01, Singapore, 138670, Singapore.
Angew Chem Int Ed Engl ; 60(31): 17131-17137, 2021 07 26.
Article em En | MEDLINE | ID: mdl-34008286
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Leucemia Mielogênica Crônica BCR-ABL Positiva / Proteínas de Fusão bcr-abl / Inibidores de Proteínas Quinases / Lisina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Leucemia Mielogênica Crônica BCR-ABL Positiva / Proteínas de Fusão bcr-abl / Inibidores de Proteínas Quinases / Lisina Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article