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Fast-Trk(B)ing the mechanism of antidepressants.
Conroy, Jacinta N; Jhaveri, Dhanisha J; Coulson, Elizabeth J.
Afiliação
  • Conroy JN; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia.
  • Jhaveri DJ; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
  • Coulson EJ; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. Electronic address: e.coulson@uq.edu.au.
Neuron ; 109(10): 1593-1595, 2021 05 19.
Article em En | MEDLINE | ID: mdl-34015266
The mechanism by which antidepressants elicit clinical improvements has proven elusive. In a recent publication in Cell, Casarotto et al. (2021) reveal a surprising direct interaction between antidepressants and TrkB. This link provides an important mechanistic insight into synaptic remodeling that may assist in the design of improved antidepressant therapeutics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor trkB / Fatores de Crescimento Neural Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor trkB / Fatores de Crescimento Neural Idioma: En Ano de publicação: 2021 Tipo de documento: Article