New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis.
Planta Med
; 88(6): 420-428, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-34015832
ABSTRACT
Four undescribed sulfoxide-containing derivatives, sinkiangenoxides A and B, (2Z, 4E)-sinkiangenoxide C, and (2E, 4E)-sinkiangenoxide C (1 â-â4 ), and one known compound, 1-(methylthio)propyl (E)-1-propenyl disulfide (5 ), were isolated from the resin of Ferula sinkiangensis. Their structures were determined based on spectroscopic methods, including IR, UV, HRESIMS, NMR, and CD analysis. Compounds 2 â-â4 showed moderate cytotoxic activities against four human cancer cell lines with IC50 values ranging from 15.0 to 40.3 µM. Sinkiangenoxide B (2 ) was shown to induce apoptosis in HepG2 cells. In addition, compound 5 effectively attenuated lipopolysaccharide-induced nitric oxide release and TNF-α, IL-1ß, IL-6, and IL-10 expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ferula
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article