Post-transplant cyclophosphamide limits reactive donor T cells and delays the development of graft-versus-host disease in a humanized mouse model.

Adhikary, Sam R; Cuthbertson, Peter; Nicholson, Leigh; Bird, Katrina M; Sligar, Chloe; Hu, Min; O'Connell, Philip J; Sluyter, Ronald; Alexander, Stephen I; Watson, Debbie

Adhikary, Sam R; Cuthbertson, Peter; Nicholson, Leigh; Bird, Katrina M; Sligar, Chloe; Hu, Min; O'Connell, Philip J; Sluyter, Ronald; Alexander, Stephen I; Watson, Debbie.

Afiliação

Adhikary SR; Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
Cuthbertson P; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Nicholson L; Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
Bird KM; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Sligar C; Westmead Institute for Medical Research, Westmead, NSW, Australia.
Hu M; Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
O'Connell PJ; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Sluyter R; Illawarra Health and Medical Research Institute, Wollongong, NSW, Australia.
Alexander SI; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia.
Watson D; Westmead Institute for Medical Research, Westmead, NSW, Australia.

Immunology ; 164(2): 332-347, 2021 10.

Article em En | MEDLINE | ID: mdl-34021907

Assuntos

Ciclofosfamida/imunologia; Doença Enxerto-Hospedeiro/imunologia; Linfócitos T Reguladores/imunologia; Animais; Células Cultivadas; Modelos Animais de Doenças; Feminino; Transplante de Células-Tronco Hematopoéticas/métodos; Humanos; Leucócitos Mononucleares/imunologia; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Doadores de Tecidos; Transplante Homólogo/métodos

Palavras-chave

graft-versus-host disease; humanized mice; post-transplant cyclophosphamide; reactive T cells; regulatory T cells; xenogeneic

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Ciclofosfamida / Doença Enxerto-Hospedeiro Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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