Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic &#969;-Ester Macrocycles in a New Multicore RiPP Natural Product.

Zhao, Gengxiang; Kosek, Dalibor; Liu, Hong-Bing; Ohlemacher, Shannon I; Blackburne, Brittney; Nikolskaya, Anastasia; Makarova, Kira S; Sun, Jiadong; Barry Iii, Clifton E; Koonin, Eugene V; Dyda, Fred; Bewley, Carole A

Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product.

Zhao, Gengxiang; Kosek, Dalibor; Liu, Hong-Bing; Ohlemacher, Shannon I; Blackburne, Brittney; Nikolskaya, Anastasia; Makarova, Kira S; Sun, Jiadong; Barry Iii, Clifton E; Koonin, Eugene V; Dyda, Fred; Bewley, Carole A.

Afiliação

Zhao G; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Kosek D; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Liu HB; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Ohlemacher SI; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Blackburne B; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, United States.
Nikolskaya A; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, United States.
Makarova KS; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, United States.
Sun J; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Barry Iii CE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20894, United States.
Koonin EV; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, United States.
Dyda F; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
Bewley CA; Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.

J Am Chem Soc ; 143(21): 8056-8068, 2021 06 02.

Article em En | MEDLINE | ID: mdl-34028251

Assuntos

Trifosfato de Adenosina/metabolismo; Produtos Biológicos/metabolismo; Ligases/metabolismo; Peptídeos/metabolismo; Trifosfato de Adenosina/química; Amidas/química; Amidas/metabolismo; Produtos Biológicos/química; Ésteres/química; Ésteres/metabolismo; Ligases/química; Compostos Macrocíclicos/química; Compostos Macrocíclicos/metabolismo; Conformação Molecular; Peptídeos/química; Processamento de Proteína Pós-Traducional

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Produtos Biológicos / Trifosfato de Adenosina / Ligases Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google