In silico analysis of non-synonymous missense SNPs (nsSNPs) in CPE, GNAS genes and experimental validation in type II diabetes mellitus through Next Generation Sequencing.

Sabiha, Bibi; Bhatti, Attya; Roomi, Sohaib; John, Peter; Ali, Johar

Sabiha, Bibi; Bhatti, Attya; Roomi, Sohaib; John, Peter; Ali, Johar.

Afiliação

Sabiha B; Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12 Islamabad, Pakistan.
Bhatti A; Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12 Islamabad, Pakistan. Electronic address: attyabhatti@gmail.com.
Roomi S; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan.
John P; Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12 Islamabad, Pakistan.
Ali J; Center for Genome Sciences, Rehman Medical College, Phase-V, Hayatabad, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Genomics ; 113(4): 2426-2440, 2021 07.

Article em En | MEDLINE | ID: mdl-34029697

Assuntos

Diabetes Mellitus Tipo 2; Polimorfismo de Nucleotídeo Único; Carboxipeptidase H; Cromograninas/genética; Diabetes Mellitus Tipo 2/genética; Subunidades alfa Gs de Proteínas de Ligação ao GTP/genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Modelos Moleculares; Estabilidade Proteica

Palavras-chave

CPE; GNAS; In silico; Non-synonymous missense SNPs; next generation sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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