Total syntheses of melodienones by redox isomerization of propargylic alcohols.
Org Biomol Chem
; 19(23): 5077-5081, 2021 06 16.
Article
em En
| MEDLINE
| ID: mdl-34032260
ABSTRACT
A remarkable base-promoted methodology for the rapid construction of the (E)- and (Z)-γ-oxo-α,ß-alkenoic ester skeletons from readily accessible vinyl propargylic alcohols through modified redox isomerization was uncovered. This approach manifested its high simplicity and efficiency with excellent tolerance of functional substituents, which led to the straightforward structural modifications of various natural products and efficient total syntheses of melodienone, homomelodienone, isomelodienone, and homoisomelodienone within 4 linear steps.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article